Sefton lab

Research interests

The Sefton lab develops artificial tissues for use in regenerative medicine.

Biomaterials and biomaterial based therapeutics, particularly cell delivery scaffolds, are agonists of biological responses.

The Sefton lab aims to improve the regenerative capacity of biomaterial-based therapeutics by understanding these unique responses and developing materials to take advantage of them. By applying fundamental principles of chemical and biomedical engineering, the Sefton lab aims to design and characterize regenerative biomaterial-based therapies for a wide range of applications.

Ortaleza, K., et al. Effect of Cell Density of a Methacrylic Acid-Based Hydrogel Implant on Embedded Islet Function and Viability. Tissue Eng Part A. doi: 10.1089/ten.TEA.2023.0155
Ortaleza, K., et al. Aspects of the alternative host response to methacrylic acid containing biomaterials. J Biomed Mater Res A. doi: 10.1002/jbm.a.37652
Won, SY., et al. Neutrophil depletion for early allogeneic islet survival in a methacrylic acid (MAA) copolymer-induced, vascularized subcutaneous space. Front. Transplant. doi: https://doi.org/10.3389/frtra.2023.1244093
Kinney SM, et al. Immunomodulation by subcutaneously injected methacrylic acid-based hydrogels and tolerogenic dendritic cells in a mouse model of autoimmune diabetes. Biomaterials. doi: https://doi.org/10.1016/j.biomaterials.2023.122265
Androschuk, A.M., et al. Methacrylic Acid-Based Regenerative Biomaterials: Explorations into the MAAgic. Regen. Eng. Transl. Med. doi: https://doi.org/10.1007/s40883-022-00263-0
Androschuk AM, et al. Methacrylic acid-based biomaterials promote peripheral innervation in the subcutaneous space of mice. Biomaterials. doi: 10.1016/j.biomaterials.2022.121764.
Sefton MV, Simmons CA. Hearts by design. Science. doi: 10.1126/science.add0829.
Kinney SM, et al. Degradable methacrylic acid-based synthetic hydrogel for subcutaneous islet transplantation. Biomaterials. doi: 10.1016/j.biomaterials.2021.121342.